Atc Core Bonding Manual Muscle
Annotation score: Annotation score: 5 out of 5 Annotation score:5 out of 5 The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome.More.Experimental evidence at protein level i This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.More. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:).
Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). By similarity Manually curated information which has been propagated from a related experimentally characterized protein.
More Manual assertion inferred from sequence similarity to i. 1 Publication Manually curated information for which there is published experimental evidence. More Manual assertion based on experiment in i. Cited for: ALTERNATIVE SPLICING, CHARACTERIZATION, FUNCTION. Regions Feature key Position(s) Description Actions Graphical view Length This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.More.DNA binding i 8 The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:More.GO - Molecular function i.
Source: ProtInc Traceable Author Statement Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries. More information in the GO evidence code guide Traceable author statement i. Source: BHF-UCL. Source: BHF-UCL.
Source: Ensembl. Source: BHF-UCL.
Source: BHF-UCL. Source: BHF-UCL. Source: ProtInc Traceable Author Statement Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.
More information in the GO evidence code guide Traceable author statement i. The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:More.GO - Biological process i. Source: UniProtKB Inferred from Direct Assay Used to indicate a direct assay for the function, process or component indicated by the GO term. More information in the GO evidence code guide Inferred from direct assay i.
Source: Reactome. Source: MGI Inferred from Direct Assay Used to indicate a direct assay for the function, process or component indicated by the GO term. More information in the GO evidence code guide Inferred from direct assay i. Source: ParkinsonsUK-UCL. Source: UniProtKB Inferred from Direct Assay Used to indicate a direct assay for the function, process or component indicated by the GO term. More information in the GO evidence code guide Inferred from direct assay i. Source: UniProtKB Inferred from Direct Assay Used to indicate a direct assay for the function, process or component indicated by the GO term.
More information in the GO evidence code guide Inferred from direct assay i. Source: ProtInc Traceable Author Statement Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries. More information in the GO evidence code guide Traceable author statement i. Source: Reactome. UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.More.Keywords i Molecular function, Biological process, Enzyme and pathway databases Reactome - a knowledgebase of biological pathways and processesReactome i Calcineurin activates NFAT.
FCERI mediated Ca+2 mobilization. Ca2+ pathway. CLEC7A (Dectin-1) induces NFAT activation. SIGNOR Signaling Network Open ResourceSIGNOR i. This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.More.Names & Taxonomy i This subsection of the ‘Names and Taxonomy’ section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.More.Protein names i. Synonyms: NFAT2, NFATC This subsection of the ‘Names and taxonomy’ section provides information on the name(s) of the organism that is the source of the protein sequence.More.Organism i This subsection of the ‘Names and taxonomy’ section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.More.Taxonomic identifier i This subsection of the ‘Names and taxonomy’ section contains the taxonomic hierarchical classification lineage of the source organism.
It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.More.Taxonomic lineage i › › › › › › › › › › › › › › › › › › › › › › › › › › › › ›. This subsection of the “Names and Taxonomy” section is present for entries that are part of a proteome, i.e. Of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.More.Proteomes i. A UniProt proteome can consist of several components. The component name refers to the genomic component encoding a set of proteins. These range from a single component such as Viral genomes to several components as in the case of eukaryotic chromosomes.
They may also represent different stages in a genome project and include components such as contigs, scaffolds or Whole Genome Shotgun (WGS) master records.More. Component i: Chromosome 18 Organism-specific databases Eukaryotic Pathogen Database ResourcesEuPathDB i Human Gene Nomenclature DatabaseHGNC i NFATC1.
Online Mendelian Inheritance in Man (OMIM)MIM i gene. Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION. Note: Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription (PubMed:).
Nuclear translocation of NFATC1 is enhanced in the presence of TNFSF11. Nuclear translocation is decreased in the presence of FBN1 which can bind and sequester TNFSF11 (By similarity).
By similarity Manually curated information which has been propagated from a related experimentally characterized protein. More Manual assertion inferred from sequence similarity to i. 1 Publication Manually curated information for which there is published experimental evidence. More Manual assertion based on experiment in i.
Cytosol. Source: Reactome. Nucleus.
Source: HPA. Source: BHF-UCL Inferred from Direct Assay Used to indicate a direct assay for the function, process or component indicated by the GO term. More information in the GO evidence code guide Inferred from direct assay i. Source: HPA.
Source: MGI Inferred from Direct Assay Used to indicate a direct assay for the function, process or component indicated by the GO term. More information in the GO evidence code guide Inferred from direct assay i. Other locations. Source: BHF-UCL. This section provides information on the disease(s) and phenotype(s) associated with a protein.More.Pathology & Biotech i Mutagenesis Feature key Position(s) Description Actions Graphical view Length This subsection of the ‘Pathology and Biotech’ section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.More.Mutagenesis i S → A: No effect on subcellular localization.
1 This subsection of the ‘Pathology and Biotech’ section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.More.Mutagenesis i S → A: Partial nuclear translocation. 1 Publication Manually curated information for which there is published experimental evidence. More Manual assertion based on experiment in i. Cited for: MUTAGENESIS OF SER-172 AND SER-187. 1 This subsection of the ‘Pathology and Biotech’ section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.More.Mutagenesis i S → A: No effect on subcellular localization. 1 Publication Manually curated information for which there is published experimental evidence. More Manual assertion based on experiment in i.
Cited for: PHOSPHORYLATION LARGE SCALE ANALYSIS AT SER-233, IDENTIFICATION BY MASS SPECTROMETRY LARGE SCALE ANALYSIS. 1 This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding lipids, glycans and protein cross-links.More.Modified residue i Phosphoserine By similarity Manually curated information which has been propagated from a related experimentally characterized protein. More Manual assertion inferred from sequence similarity to i.
1 This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding lipids, glycans and protein cross-links.More.Modified residue i Phosphoserine; by PKA 1 Publication Manually curated information for which there is published experimental evidence. More Manual assertion based on experiment in i. Cited for: PHOSPHORYLATION AT SER-245; SER-269 AND SER-294. 1 This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding lipids, glycans and protein cross-links.More.Modified residue i Phosphoserine; by PKA 1 Publication Manually curated information for which there is published experimental evidence. More Manual assertion based on experiment in i.
Cited for: PHOSPHORYLATION AT SER-245; SER-269 AND SER-294. 1 This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding lipids, glycans and protein cross-links.More.Modified residue i Phosphoserine; by PKA 1 Publication Manually curated information for which there is published experimental evidence. More Manual assertion based on experiment in i. Cited for: PHOSPHORYLATION AT SER-245; SER-269 AND SER-294.
1 This subsection of the PTM/processing section describes post-translational modifications (PTMs). This subsection complements the information provided at the sequence level or describes modifications for which position-specific data is not yet available.More.Post-translational modification i. Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION. UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.More.Keywords - PTM i Proteomic databases MaxQB - The MaxQuant DataBaseMaxQB i PaxDb, a database of protein abundance averages across all three domains of lifePaxDb i PeptideAtlasPeptideAtlas i PRoteomics IDEntifications databasePRIDE i PTM databases iPTMnet integrated resource for PTMs in systems biology contextiPTMnet i Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.PhosphoSitePlus i. This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.More.Expression i This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’.Examples: P92958, Q8TDN4, O14734More.Tissue specificity i.
Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T-cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T-cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and adult brain, strongest in corpus callosum. 1 Publication Manually curated information for which there is published experimental evidence. More Manual assertion based on experiment in i.
Only isoforms A are inducibly expressed in T lymphocytes upon activation of the T-cell receptor (TCR) complex. Induced after co-addition of phorbol 12-myristate 13-acetate (PMA) and ionomycin. Also induced after co-addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) and ionomycin. Weakly induced with PMA, ionomycin and cyclosporin A. Gene expression databases Bgee dataBase for Gene Expression EvolutionBgee i CleanEx database of gene expression profilesCleanEx i ExpressionAtlas, Differential and Baseline ExpressionExpressionAtlas i baseline and differential. Genevisible search portal to normalized and curated expression data from GenevestigatorGenevisible i HS.
Organism-specific databases Human Protein AtlasHPA i. This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.More.Interaction i This subsection of the ‘Interaction’ section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the ‘Function’ section).More.Subunit structure i. Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1.
Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers. 1 Publication Manually curated information for which there is published experimental evidence. More Manual assertion based on experiment in i. Cited for: STRUCTURE BY NMR OF IN COMPLEX WITH DNA.
This subsection of the ‘Interaction’ section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the IntAct database. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.More.Binary interactions i With Entry #Exp. IntAct Notes ATF1 3 ATF2 2 ATF3 2 CREB1 3 HOXC13 2 JUN 5 OGT 2 PPP3CA 4 The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:More.GO - Molecular function i. Source: BHF-UCL. Source: Ensembl.
Source: BHF-UCL. Legend: Helix Turn Beta strand PDB Structure known for this area Feature key Position(s) Description Actions Graphical view Length This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined beta strands within the protein sequence.More.Beta strand i Combined sources Manually validated information inferred from a combination of experimental and computational evidence. More Manual assertion inferred from combination of experimental and computational evidence i.
7 This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined beta strands within the protein sequence.More.Beta strand i Combined sources Manually validated information inferred from a combination of experimental and computational evidence. More Manual assertion inferred from combination of experimental and computational evidence i. 3 This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined beta strands within the protein sequence.More.Beta strand i Combined sources Manually validated information inferred from a combination of experimental and computational evidence. More Manual assertion inferred from combination of experimental and computational evidence i. 3 This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined beta strands within the protein sequence.More.Beta strand i Combined sources Manually validated information inferred from a combination of experimental and computational evidence.
More Manual assertion inferred from combination of experimental and computational evidence i. 6 This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined beta strands within the protein sequence.More.Beta strand i Combined sources Manually validated information inferred from a combination of experimental and computational evidence. More Manual assertion inferred from combination of experimental and computational evidence i. 3 This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined beta strands within the protein sequence.More.Beta strand i Combined sources Manually validated information inferred from a combination of experimental and computational evidence. More Manual assertion inferred from combination of experimental and computational evidence i. 9 This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined beta strands within the protein sequence.More.Beta strand i Combined sources Manually validated information inferred from a combination of experimental and computational evidence.
More Manual assertion inferred from combination of experimental and computational evidence i. 3 This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined beta strands within the protein sequence.More.Beta strand i Combined sources Manually validated information inferred from a combination of experimental and computational evidence.
More Manual assertion inferred from combination of experimental and computational evidence i. 3 This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined beta strands within the protein sequence.More.Beta strand i Combined sources Manually validated information inferred from a combination of experimental and computational evidence. More Manual assertion inferred from combination of experimental and computational evidence i. 8 This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined beta strands within the protein sequence.More.Beta strand i Combined sources Manually validated information inferred from a combination of experimental and computational evidence. More Manual assertion inferred from combination of experimental and computational evidence i. 3 This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined helical regions within the protein sequence.More.Helix i Combined sources Manually validated information inferred from a combination of experimental and computational evidence. More Manual assertion inferred from combination of experimental and computational evidence i.
Goldfinger radio drama podcasts. I got a copy from. And, in case you were wondering, it returns Honeychile to the nude. It has that, sense of place, that a film gives, it plays up the mystery element, (which the movie downplays) and compresses the narrative with a “” way that good audio drama really excels. In the movie she’s singing “Underneath The Mango Tree,” in the novel she’s whistling “.” Fleming describes “Marianne” as “a plaintive little Calypso that has now been cleaned up and made famous outside Jamaica.” And it’s “Marianne” that’s used in the most recent incarnation of the Doctor No story, the BBC audio dramatization! I really like the movie, and the novel is definitely up there, but for me, now that I’ve heard it, the 2008 BBC audio dramatization of Doctor No is now my preferred version.
5 This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined beta strands within the protein sequence.More.Beta strand i Combined sources Manually validated information inferred from a combination of experimental and computational evidence. More Manual assertion inferred from combination of experimental and computational evidence i. 3 This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined beta strands within the protein sequence.More.Beta strand i Combined sources Manually validated information inferred from a combination of experimental and computational evidence. More Manual assertion inferred from combination of experimental and computational evidence i. 12 This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined hydrogen-bonded turns within the protein sequence. These elements correspond to the DSSP secondary structure code ‘T’.More.Turn i Combined sources Manually validated information inferred from a combination of experimental and computational evidence.
More Manual assertion inferred from combination of experimental and computational evidence i. 3 This subsection of the ‘Structure’ section is used to indicate the positions of experimentally determined beta strands within the protein sequence.More.Beta strand i Combined sources Manually validated information inferred from a combination of experimental and computational evidence. More Manual assertion inferred from combination of experimental and computational evidence i. 13 3D structure databases Select the link destinations: Protein Data Bank EuropePDBe i Protein Data Bank RCSBRCSB PDB i Protein Data Bank JapanPDBj i. Isoforms C have a C-terminal part with an additional trans-activation domain, TAD-B, which acts as a transcriptional activator. Isoforms B have a shorter C-terminal part without complete TAD-B which acts as a transcriptional repressor. UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure.
Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.More.Keywords - Domain i Phylogenomic databases evolutionary genealogy of genes: Non-supervised Orthologous GroupseggNOG i Eukaryota. Ensembl GeneTreeGeneTree i The HOGENOM Database of Homologous Genes from Fully Sequenced OrganismsHOGENOM i The HOVERGEN Database of Homologous Vertebrate GenesHOVERGEN i InParanoid: Eukaryotic Ortholog GroupsInParanoid i KEGG Orthology (KO)KO i Identification of Orthologs from Complete Genome DataOMA i Database of Orthologous GroupsOrthoDB i Database for complete collections of gene phylogeniesPhylomeDB i TreeFam database of animal gene treesTreeFam i Family and domain databases Gene3D Structural and Functional Annotation of Protein FamiliesGene3D i 1 hit.
Integrated resource of protein families, domains and functional sitesInterPro i Ig-likefold. The PANTHER Classification SystemPANTHER i PTHR12533. Pfam protein domain databasePfam i RHDdimer. Protein Motif fingerprint database; a protein domain databasePRINTS i NUCFACTORATC. Simple Modular Architecture Research Tool; a protein domain databaseSMART i IPT. Superfamily database of structural and functional annotationSUPFAM i SSF49417.
PROSITE; a protein domain and family databasePROSITE i REL2. This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.More.Sequence s (10) i This subsection of the ‘Sequence’ section indicates if the canonical sequence displayed by default in the entry is complete or not.More.Sequence status i: Complete.
This entry describes 10 This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.More. Isoforms i produced by alternative splicing and alternative initiation. The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates. It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.
However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs). The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x64 + x4 + x3 + x + 1.
The algorithm is described in the ISO 3309 standard. Press W.H., Flannery B.P., Teukolsky S.A. And Vetterling W.T. Cyclic redundancy and other checksums Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)) Checksum: iE72FAB10ECEB2D66. The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.
It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low. However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).
The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x64 + x4 + x3 + x + 1. The algorithm is described in the ISO 3309 standard. Press W.H., Flannery B.P., Teukolsky S.A. And Vetterling W.T. Cyclic redundancy and other checksums Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)) Checksum: iC02F3B03F2019BB1.
The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.
It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low. However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).
The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x64 + x4 + x3 + x + 1. The algorithm is described in the ISO 3309 standard. Press W.H., Flannery B.P., Teukolsky S.A.
And Vetterling W.T. Cyclic redundancy and other checksums Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)) Checksum: i57650B6E2A9A219C. The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates. It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low. However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs). The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x64 + x4 + x3 + x + 1.
The algorithm is described in the ISO 3309 standard. Press W.H., Flannery B.P., Teukolsky S.A. And Vetterling W.T.
Cyclic redundancy and other checksums Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)) Checksum: i28469C5BE89B00CC. The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates. It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.
However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs). The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x64 + x4 + x3 + x + 1. The algorithm is described in the ISO 3309 standard. Press W.H., Flannery B.P., Teukolsky S.A. And Vetterling W.T. Cyclic redundancy and other checksums Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)) Checksum: iDBF68E35846E998D. The checksum is a form of redundancy check that is calculated from the sequence.
Atc Core Bonding Manual Muscles
It is useful for tracking sequence updates. It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.
However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs). The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x64 + x4 + x3 + x + 1. The algorithm is described in the ISO 3309 standard. Press W.H., Flannery B.P., Teukolsky S.A. And Vetterling W.T. Cyclic redundancy and other checksums Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)) Checksum: i8708706F1C8938AC. The checksum is a form of redundancy check that is calculated from the sequence.
It is useful for tracking sequence updates. It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low. However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).
The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x64 + x4 + x3 + x + 1. The algorithm is described in the ISO 3309 standard. Press W.H., Flannery B.P., Teukolsky S.A.
And Vetterling W.T. Cyclic redundancy and other checksums Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)) Checksum: iD9D7060FEB4E81DF. The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates. It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low. However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).
The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x64 + x4 + x3 + x + 1. The algorithm is described in the ISO 3309 standard.
Press W.H., Flannery B.P., Teukolsky S.A. And Vetterling W.T.
Cyclic redundancy and other checksums Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)) Checksum: iB797CFCFF28F8976. The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates. It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low. However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).
The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x64 + x4 + x3 + x + 1. The algorithm is described in the ISO 3309 standard. Press W.H., Flannery B.P., Teukolsky S.A. And Vetterling W.T. Cyclic redundancy and other checksums Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)) Checksum: i4A4F5475DF755F89.
10 20 30 40 50 MLQLFIGTAD DRLLRPHAFY QVHRITGKTV STTSHEAILS NTKVLEIPLL 60 70 80 90 100 PENSMRAVID CAGILKLRNS DIELRKGETD IGRKNTRVRL VFRVHVPQPS 110 120 130 140 150 GRTLSLQVAS NPIECSQRSA QELPLVEKQS TDSYPVVGGK KMVLSGHNFL 160 170 180 190 200 QDSKVIFVEK APDGHHVWEM EAKTDRDLCK PNSLVVEIPP FRNQRITSPV 210 220 230 240 250 HVSFYVCNGK RKRSQYQRFT YLPANVPIIK TEPTDDYEPA PTCGPVSQGL 260 270 280 290 300 SPLPRPYYSQ QLAMPPDPSS CLVAGFPPCP QRSTLMPAAP GVSPKLHDLS 310 320 330 340 350 PAAYTKGVAS PGHCHLGLPQ PAGEAPAVQD VPRPVATHPG SPGQPPPALL PQQ. The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates. It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low. However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs). The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x64 + x4 + x3 + x + 1. The algorithm is described in the ISO 3309 standard.
Press W.H., Flannery B.P., Teukolsky S.A. And Vetterling W.T. Cyclic redundancy and other checksums Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)) Checksum: iAB8DEB0C451190DD. Experimental Info Feature key Position(s) Description Actions Graphical view Length This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.More.Sequence conflict i G → S in (PubMed:).
Curated 1 This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.More.Sequence conflict i R → Q in (PubMed:). Curated 1 Natural variant Feature key Position(s) Description Actions Graphical view Length This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.More.Natural variant i VAR057145.
Corresponds to variant. 1 This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.More.Natural variant i VAR036529 in a colorectal cancer sample; somatic mutation. 1 Publication Manually curated information for which there is published experimental evidence. More Manual assertion based on experiment in i. Cited for: VARIANT LARGE SCALE ANALYSIS THR-315.
Corresponds to variant. 1 This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.More.Natural variant i VAR057146.
Corresponds to variant. 1 Alternative sequence Feature key Position(s) Description Actions Graphical view Length This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s).
The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.More.Alternative sequence i VSP053806 Missing in isoform. Curated 472 This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.More.Alternative sequence i VSP005590 MPSTSKSAEE → MTGLEDQEFDFEFLFEFNQR DEGAAAAAP in isoform, isoform, isoform and isoform.
3 Publications Manually curated information that is based on statements in scientific articles for which there is no experimental support. More Manual assertion based on opinion in i. Cited for: NUCLEOTIDE SEQUENCE MRNA (ISOFORMS C-ALPHA; IA-DELTAIX AND IB-DELTAIX), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
42 This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.More.Alternative sequence i VSP018978 Missing in isoform. Curated 36 This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.More.Alternative sequence i VSP047820 Missing in isoform and isoform. 1 Publication Manually curated information that is based on statements in scientific articles for which there is no experimental support.
More Manual assertion based on opinion in i. Cited for: NUCLEOTIDE SEQUENCE MRNA (ISOFORMS C-ALPHA; IA-DELTAIX AND IB-DELTAIX), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
230 This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.More.Alternative sequence i VSP005591 VPIIKAPTCG → GNAIFLTVSREHERVGCFF in isoform, isoform and isoform. 3 Publications Manually curated information that is based on statements in scientific articles for which there is no experimental support.
More Manual assertion based on opinion in i. Cited for: NUCLEOTIDE SEQUENCE LARGE SCALE MRNA (ISOFORM A-ALPHA). 19 This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.
The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.More.Alternative sequence i VSP005592 Missing in isoform, isoform and isoform. 3 Publications Manually curated information that is based on statements in scientific articles for which there is no experimental support.
More Manual assertion based on opinion in i. Cited for: NUCLEOTIDE SEQUENCE LARGE SCALE MRNA (ISOFORM A-ALPHA). 227 This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.More.Alternative sequence i VSP005593 Missing in isoform, isoform and isoform. 2 Publications Manually curated information that is based on statements in scientific articles for which there is no experimental support. More Manual assertion based on opinion in i.
Links Updated mRNA. No translation available. No translation available. The Consensus CDS (CCDS) projectCCDS i Protein sequence database of the Protein Information ResourcePIR i NCBI Reference SequencesRefSeq i UniGene gene-oriented nucleotide sequence clustersUniGene i Genome annotation databases Ensembl eukaryotic genome annotation projectEnsembl i;;. Database of genes from NCBI RefSeq genomesGeneID i KEGG: Kyoto Encyclopedia of Genes and GenomesKEGG i UCSC genome browserUCSC i human. UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.More.Keywords - Coding sequence diversity i.
Protein Similar proteins Organisms Length Cluster ID Cluster name Size O95644 943 Cluster: Nuclear factor of activated T-cells, cytoplasmic 1 4 O95644-2 716 Cluster: Isoform A-alpha of Nuclear factor of activated T-cells, cytoplasmic 1 2 O95644-5 930 Cluster: Isoform C-beta of Nuclear factor of activated T-cells, cytoplasmic 1 2 O95644-6 930 Cluster: Isoform C-beta of Nuclear factor of activated T-cells, cytoplasmic 1 2 O95644-8 716 Cluster: Isoform A-alpha of Nuclear factor of activated T-cells, cytoplasmic 1 2. Links Updated mRNA. No translation available. No translation available.
The Consensus CDS (CCDS) projectCCDS i Protein sequence database of the Protein Information ResourcePIR i NCBI Reference SequencesRefSeq i UniGene gene-oriented nucleotide sequence clustersUniGene i 3D structure databases Select the link destinations: Protein Data Bank EuropePDBe i Protein Data Bank RCSBRCSB PDB i Protein Data Bank JapanPDBj i. This section provides general information on the entry.More.Entry information i This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.More.Entry name i NFAC1HUMAN This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.More.Accession i Primary (citable) accession number: O95644 Secondary accession number(s): B5B2M4.
B5B2M5, B5B2M6, B5B2M7, B5B2M8, B5B2M9, B5B2N1, Q12865, Q15793, Q2M1S3 This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the canonical sequence are also displayed.More.Entry history i Integrated into UniProtKB/Swiss-Prot: December 1, 2000 Last sequence update: December 1, 2000 Last modified: December 20, 2017 This is version 189 of the entry and version 3 of the sequence. This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).More.Entry status i Reviewed (UniProtKB/Swiss-Prot) Annotation program Disclaimer Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. This section contains any relevant information that doesn’t fit in any other defined sectionsMore.Miscellaneous i UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.More.Keywords - Technical term i, Documents. Human chromosome 18: entries, gene names and cross-references to MIM.
List of human entries with polymorphisms or disease mutations. Index of human polymorphisms and disease mutations. Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot. Index of Protein Data Bank (PDB) cross-references This will take you to the BLAST page where you can edit options More. Tools. Core data. Supporting data.
Information.